Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4369067 | 0.83 | APP (0.53) | MEN1KMT2AAPPNPC1RAB9A | |
| SCHEMBL4371698 | 0.83 | MEN1 (0.44) | MEN1KMT2AAPPNPC1RAB9A | |
| SCHEMBL4372447 | 0.83 | MEN1 (0.48) | MEN1KMT2AAPPNPC1RAB9A | |
| SCHEMBL4366818 | 0.81 | APP (0.40) | MEN1KMT2AAPPNPC1RAB9A | |
| SCHEMBL2993032 | 0.80 | MEN1 (0.56) | MEN1KMT2AAPPNPC1RAB9A | |
| SCHEMBL28853802 | 0.76 | PDE4B (0.42) | MEN1KMT2AAPPGAAMAPK1 | |
| SCHEMBL2989969 | 0.73 | MEN1 (0.52) | MEN1KMT2AAPPNPC1RAB9A | |
| SCHEMBL4379011 | 0.72 | LMNA (0.40) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4369064 | 0.69 | APP (0.50) | MEN1KMT2AAPPNPC1RAB9A | |
| SCHEMBL4375404 | 0.68 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083011-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | Tian Jin Hemay Bio-Tech Co., Ltd. (CN) | 2009-07-29 | — | — | EP | disclosed |