Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IL18 | Q14116 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24953926 | 1.00 | TRPM8 (0.38) | TRPM8SCN9AKDM4EMEN1LMNA | |
| SCHEMBL24953654 | 1.00 | TRPM8 (0.38) | TRPM8SCN9AKDM4EMEN1LMNA | |
| SCHEMBL24952936 | 0.90 | GCK (0.34) | RAB9AALDH1A1 | |
| SCHEMBL24953564 | 0.90 | JAK2 (0.39) | RAB9AJAK2JAK1JAK3 | |
| SCHEMBL24954128 | 0.89 | CYP3A4 (0.34) | — | |
| SCHEMBL24952899 | 0.89 | GCK (0.35) | MEN1KMT2AALDH1A1 | |
| SCHEMBL24953922 | 0.88 | SCN9A (0.41) | SCN9AKDM4EMEN1LMNAPOLB | |
| SCHEMBL24953942 | 0.88 | KDR (0.36) | — | |
| SCHEMBL24952962 | 0.87 | GCK (0.44) | TRPM8ALDH1A1HPGD | |
| SCHEMBL24953737 | 0.87 | GCK (0.44) | TRPM8ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114845709-A | MRGPRX2 antagonists for use in treating inflammatory disorders | 德米拉公司 | 2022-08-02 | — | — | CN | disclosed |