Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.41 |
| ▸ | USP2 | O75604 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28198777 | 0.88 | PIK3CA (0.44) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL28029238 | 0.85 | MTOR (0.44) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL28029224 | 0.85 | MTOR (0.43) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL28029222 | 0.85 | CYP1A2 (0.54) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL28948857 | 0.83 | GRIN1 (0.46) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL28029213 | 0.82 | ADORA2A (0.44) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL28028874 | 0.82 | MTOR (0.47) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL28028875 | 0.81 | MTOR (0.42) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL28821952 | 0.81 | MTOR (0.47) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL28028882 | 0.81 | MTOR (0.59) | MEN1KMT2AUSP2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107976546-A | Inhibition of phosphorylation to TOR kinase inhibiting activities mark PRAS40, GSK3- β or P70S6K1 | 西格诺药品有限公司 | 2018-05-01 | — | — | CN | disclosed |
| CN-104870998-B | inhibition of phosphorylation of PRAS40, GSK3- β or P70S6K1 as a marker of TOR kinase inhibitory activity | 西格诺药品有限公司 | 2018-02-02 | — | — | CN | disclosed |