SCHEMBL28856372

SCHEMBL28856372

FC(F)(F)c1cc(CN2CCNCC2)cc(N2CCOCC2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 1/20 0.56
CYP3A4 P08684 3/20 0.52
CYP2D6 P10635 3/20 0.52
TSHR P16473 1/20 0.47
MEN1 O00255 1/20 0.45
TP53 P04637 1/20 0.45
KMT2A Q03164 1/20 0.45
ALDH1A1 P00352 2/20 0.45
HTR3E A5X5Y0 1/20 0.45
HTR3B O95264 1/20 0.45
HTR1D P28221 1/20 0.45
HTR2C P28335 1/20 0.45
HTR3A P46098 1/20 0.45
HTR3D Q70Z44 1/20 0.45
HTR3C Q8WXA8 1/20 0.45
SIGMAR1 Q99720 1/20 0.45
MAPT P10636 1/20 0.44
THRB P10828 1/20 0.44
HIF1A Q16665 2/20 0.43
EPAS1 Q99814 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20503588 0.88 ADRB1 (0.60) ADRB1CYP3A4CYP2D6TSHRMEN1
SCHEMBL19262510 0.82 CYP2D6 (0.72) ADRB1CYP3A4CYP2D6TSHRMEN1
SCHEMBL28201363 0.81 ADRB1 (0.52) ADRB1CYP3A4CYP2D6TSHRMEN1
SCHEMBL20676125 0.80 CYP2D6 (0.70) ADRB1CYP3A4CYP2D6TSHRMEN1
SCHEMBL14117336 0.78 ADRB1 (0.45) ADRB1CYP2D6TSHRALDH1A1MAPT
SCHEMBL18064933 0.78 CYP2D6 (0.43) ADRB1CYP3A4CYP2D6TSHRMEN1
SCHEMBL28201369 0.77 CYP3A4 (0.47) ADRB1CYP3A4CYP2D6TSHRMEN1
SCHEMBL19992897 0.77 CYP2D6 (0.50) ADRB1CYP3A4CYP2D6TSHRMEN1
SCHEMBL19262611 0.76 CYP3A4 (0.61) ADRB1CYP3A4CYP2D6TSHRMEN1
SCHEMBL15265439 0.76 AGXT (0.56) ADRB1CYP3A4CYP2D6TP53ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107660199-A Piperazine carbamate and its preparation and application 阿比德治疗公司 2018-02-02 CN disclosed