Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.84 |
| ▸ | JAK1 | P23458 | 19/20 | 0.84 |
| ▸ | JAK3 | P52333 | 4/20 | 0.67 |
| ▸ | CIT | O14578 | 1/20 | 0.65 |
| ▸ | GAK | O14976 | 1/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.65 |
| ▸ | ULK1 | O75385 | 1/20 | 0.65 |
| ▸ | PRKCB | P05771 | 1/20 | 0.65 |
| ▸ | RET | P07949 | 1/20 | 0.65 |
| ▸ | PRKCA | P17252 | 1/20 | 0.65 |
| ▸ | PRKACA | P17612 | 1/20 | 0.65 |
| ▸ | MARK3 | P27448 | 1/20 | 0.65 |
| ▸ | TYK2 | P29597 | 1/20 | 0.65 |
| ▸ | STAT3 | P40763 | 1/20 | 0.65 |
| ▸ | CLK1 | P49759 | 1/20 | 0.65 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.65 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.65 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.65 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28857140 | 0.92 | JAK2 (0.80) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL2397114 | 0.92 | JAK2 (1.00) | JAK2JAK1 | |
| SCHEMBL15389165 | 0.89 | JAK2 (0.73) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL872208 | 0.88 | JAK2 (0.81) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL872396 | 0.88 | JAK2 (0.82) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL872135 | 0.87 | JAK2 (0.69) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL28857097 | 0.87 | JAK2 (0.65) | JAK2JAK1 | |
| SCHEMBL871174 | 0.86 | JAK2 (0.66) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL28857067 | 0.86 | JAK2 (0.71) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL28856997 | 0.85 | JAK2 (0.64) | JAK2JAK1JAK3CITGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114149437-A | Pyrrolopyrimidine five-membered nitrogen heterocyclic derivative and preparation method and application thereof | 安徽大学 | 2022-03-08 | — | — | CN | claimed |