SCHEMBL28857097

SCHEMBL28857097

N#CCC1(n2ccc(-c3ncnc4[nH]ccc34)c2)CN(C(=O)Cc2ccccc2)C1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 19/20 0.65
JAK1 P23458 11/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28857055 0.87 JAK2 (0.84) JAK2JAK1
SCHEMBL28857059 0.86 JAK2 (0.65) JAK2JAK1
SCHEMBL28857106 0.84 JAK2 (0.66) JAK2JAK1
SCHEMBL28857140 0.80 JAK2 (0.80) JAK2JAK1
SCHEMBL2397114 0.79 JAK2 (1.00) JAK2JAK1
SCHEMBL871313 0.79 JAK2 (0.74) JAK2JAK1
SCHEMBL2396226 0.78 JAK2 (1.00) JAK2JAK1
SCHEMBL29422117 0.78 JAK2 (1.00) JAK2JAK1
SCHEMBL2395358 0.77 JAK2 (0.86) JAK2JAK1
SCHEMBL28856997 0.77 JAK2 (0.64) JAK2JAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114149437-A Pyrrolopyrimidine five-membered nitrogen heterocyclic derivative and preparation method and application thereof 安徽大学 2022-03-08 CN claimed