Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 3/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10987104 | 0.74 | CYP2D6 (0.50) | SMN1; SMN2CRHR1NOTUMHSP90AB1CYP3A4 | |
| SCHEMBL17844127 | 0.72 | NOTUM (0.44) | HTTSMN1; SMN2CRHR1DPP4NOTUM | |
| SCHEMBL21223570 | 0.71 | GRM2 (0.43) | HTTSMN1; SMN2DPP4GRM2NOTUM | |
| SCHEMBL27916597 | 0.70 | GRM2 (0.43) | CRHR1DPP4GRM2NOTUMHSP90AB1 | |
| SCHEMBL3368354 | 0.70 | DPP4 (0.69) | HTTSMN1; SMN2DPP4CYP3A4 | |
| SCHEMBL29719717 | 0.70 | NOTUM (0.53) | GRM2NOTUMCYP3A4CASP3 | |
| SCHEMBL28144723 | 0.67 | CCR9 (0.47) | CRHR1NOTUMHSP90AB1CYP3A4 | |
| SCHEMBL12071484 | 0.66 | NOTUM (0.50) | GRM2NOTUMHSP90AB1CYP3A4CASP3 | |
| SCHEMBL4709705 | 0.66 | NOTUM (0.47) | HTTCRHR1GRM2NOTUMHSP90AB1 | |
| SCHEMBL13307709 | 0.66 | NOTUM (0.44) | HTTCRHR1GRM2NOTUMHSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107709326-A | Reduce the P TAU of stress-induced Triazolopyridine and triazolo pyrimidine | 巴克老龄问题研究所 | 2018-02-16 | — | — | CN | disclosed |