Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8746755 | 0.87 | MAPT (0.49) | NOTUMHSP90AB1CRHR1HSD11B1MAPT | |
| SCHEMBL9149821 | 0.86 | NOTUM (0.43) | NOTUMHSP90AB1IDO1CRHR1MAPT | |
| SCHEMBL11626670 | 0.84 | IDO1 (0.45) | NOTUMIDO1HSD11B1MAPTHPGD | |
| SCHEMBL4715174 | 0.83 | ALPL (0.42) | HSP90AB1CRHR1MAPTHPGDNPBWR1 | |
| SCHEMBL3755589 | 0.77 | IKBKB (0.41) | NOTUMHPGDMAP3K14GAAALOX15 | |
| SCHEMBL11623822 | 0.76 | NPC1 (0.38) | HSP90AB1CRHR1HSD11B1MAPTHPGD | |
| SCHEMBL16201404 | 0.75 | CRHR1 (0.44) | NOTUMHSP90AB1CRHR1CYP3A4CYP1A2 | |
| SCHEMBL6846877 | 0.75 | IKBKE (0.46) | NOTUMIDO1GAA | |
| SCHEMBL29719717 | 0.75 | NOTUM (0.53) | NOTUMIDO1HSD11B1CASP3CYP3A4 | |
| SCHEMBL11620981 | 0.75 | DCUN1D1 (0.44) | NOTUMIDO1MAPTHPGDCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996588-A1 | NOVEL DUAL ACTION RECEPTORS ANTAGONISTS (DARA) AT THE ATI AND ETA RECEPTORS | Torrent Pharmaceuticals Ltd (IN) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007100295-A1 | NOVEL DUAL ACTION RECEPTORS ANTAGONISTS (DARA) AT THE ATI AND ETA RECEPTORS | TORRENT PHARMACEUTICALS LTD (IN) | 2007-09-07 | — | — | WO | disclosed |
| US-4072498-A | HERBICIDES | THE UPJOHN COMPANY (US) | 1978-02-07 | — | — | US | disclosed |