⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10789600 | 0.72 | — | — | |
| SCHEMBL25786 | 0.69 | — | — | |
| SCHEMBL28290729 | 0.69 | — | — | |
| SCHEMBL409162 | 0.69 | — | — | |
| SCHEMBL2163536 | 0.67 | — | — | |
| SCHEMBL16532961 | 0.67 | — | — | |
| SCHEMBL1361240 | 0.67 | — | — | |
| SCHEMBL27594831 | 0.67 | — | — | |
| SCHEMBL262786 | 0.67 | — | — | |
| SCHEMBL28489961 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113736782-B | Compositions and methods for inhibiting TMPRSS6 gene expression | 阿尔尼拉姆医药品有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-118302525-A | Complement Factor B (CFB) iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-118265786-A | Microtubule-associated protein Tau (MAPT) iRNA pharmaceutical compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-118251494-A | Compositions and methods for modulating KRAS expression | 美国微哲默理有限责任公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-118215735-A | APP iRNA compositions for treating or preventing diseases characterized by enlarged endosomes and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-118202046-A | Modified small interfering RNA molecules with reduced off-target effects | 中天(上海)生物科技有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-118176299-A | Compositions and methods for modulating NLRP3 or NLRP1 expression | 美国微哲默理有限责任公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-118176300-A | Huntington (HTT) iRNA agent compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-118076361-A | Cell death-inducing DFFA-like effector B (CIDEB) iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-117999339-A | Scale-up system and method for continuous transfection of cells | 生命科技股份有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-117015601-A | Methods and compositions for ADAR-mediated SERPINA1 editing | 科罗生物公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-116997326-A | Strategies for developing genomic editing Spherical Nucleic Acids (SNAs) | 西北大学 | 2023-11-03 | — | — | CN | disclosed |
| CN-116964202-A | Interfering RNA targeting severe acute respiratory syndrome related coronaviruses and use thereof for the treatment of covd-19 | 中天(上海)生物科技有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116964204-A | Angiopoietin-like 3 (ANGPTL 3) iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116744941-A | RNA production | 生物技术欧洲股份公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-116529372-A | Coagulation factor V (F5) iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-116390943-A | Engineered hepatitis b virus neutralizing antibodies and uses thereof | 维尔生物科技有限公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-109476718-B | Combination of MRNA encoding immunomodulatory polypeptides and uses thereof | 莫得纳特斯公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-112107693-B | Liposome particles, method for preparing said liposome particles and use thereof | 西北大学 | 2023-05-26 | — | — | CN | disclosed |
| CN-115176004-A | Complement component C3 iRNA compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2022-10-11 | — | — | CN | disclosed |