SCHEMBL28858196

SCHEMBL28858196

C=CCOC(=O)C(F)(F)F.CCCC[Si](C)C

nearest known ligand 0.45

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.45
HPGD P15428 1/20 0.35
FAAH O00519 11/20 0.33
CES2 O00748 4/20 0.33
CES1 P23141 8/20 0.33
MEN1 O00255 1/20 0.33
CYP1A2 P05177 1/20 0.33
KMT2A Q03164 1/20 0.33
HSD17B10 Q99714 1/20 0.33
EPHX1 P07099 1/20 0.30
CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27810338 0.82 MEN1 (0.39) FAAHCES2CES1MEN1CYP1A2
SCHEMBL1082749 0.81 CYP3A4 (0.41) TSHRMEN1KMT2AHSD17B10CYP3A4
Ammonia Solution, Strong SCHEMBL11233126 0.79 CYP3A4 (0.39) TSHRMEN1KMT2AHSD17B10CYP3A4
SCHEMBL28427366 0.79 CYP3A4 (0.39) TSHRMEN1KMT2AHSD17B10CYP3A4
SCHEMBL11444238 0.79 CYP3A4 (0.39) TSHRMEN1KMT2AHSD17B10CYP3A4
SCHEMBL28761387 0.79 CYP3A4 (0.39) TSHRMEN1KMT2AHSD17B10CYP3A4
SCHEMBL29506833 0.79 CYP3A4 (0.39) TSHRMEN1KMT2AHSD17B10CYP3A4
Trifluoroacetic Acid SCHEMBL28119416 0.76 CYP3A4 (0.37) TSHRHSD17B10CYP3A4
SCHEMBL19105318 0.76 TSHR (0.49) TSHRHPGDFAAHCES2CES1
SCHEMBL28292315 0.74 MAPK1 (0.38) TSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104176393-B Pressurized delivered container, the keeping method for having used it and liquid relief method 中央硝子株式会社 2018-03-16 CN disclosed