SCHEMBL28858488

SCHEMBL28858488

Cl/C(I)=C(/Cl)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.46
DAO P14920 1/20 0.46
NAPRT Q6XQN6 1/20 0.46
ALDH1A1 P00352 4/20 0.45
HIF1A Q16665 2/20 0.45
CES1 P23141 5/20 0.39
CES2 O00748 4/20 0.39
SRD5A2 P31213 1/20 0.39
ESR1 P03372 1/20 0.37
MAPK1 P28482 2/20 0.37
TRPA1 O75762 1/20 0.37
GSK3B P49841 1/20 0.37
F2 P00734 2/20 0.36
CYP3A4 P08684 2/20 0.36
MAPT P10636 2/20 0.36
BLM P54132 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
F10 P00742 1/20 0.36
F12 P00748 1/20 0.36
F7 P08709 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28858535 1.00 TSHR (0.46) TSHRDAONAPRTALDH1A1HIF1A
SCHEMBL28858491 1.00 TSHR (0.46) TSHRDAONAPRTALDH1A1HIF1A
SCHEMBL28858448 0.83 TSHR (0.46) TSHRDAONAPRTALDH1A1HIF1A
SCHEMBL3940728 0.82 TSHR (0.56) TSHRDAONAPRTALDH1A1HIF1A
SCHEMBL3940726 0.82 TSHR (0.56) TSHRDAONAPRTALDH1A1HIF1A
SCHEMBL28858496 0.80 CES1 (0.41) TSHRDAONAPRTALDH1A1HIF1A
SCHEMBL28858493 0.80 CES1 (0.41) TSHRDAONAPRTALDH1A1HIF1A
SCHEMBL28858494 0.79 ALDH1A1 (0.47) TSHRDAONAPRTALDH1A1HIF1A
SCHEMBL28858497 0.79 ALDH1A1 (0.47) TSHRDAONAPRTALDH1A1HIF1A
SCHEMBL28858549 0.79 ALDH1A1 (0.42) TSHRDAONAPRTALDH1A1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115197046-B Halogenation method of unsaturated hydrocarbon 华南理工大学 2023-12-15 CN disclosed
CN-115197046-A Halogenation method of unsaturated hydrocarbon 华南理工大学 2022-10-18 CN disclosed