Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 3/20 | 0.55 |
| ▸ | GABRD | O14764 | 3/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.55 |
| ▸ | GABRE | P78334 | 3/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.55 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.55 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.55 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | ELANE | P08246 | 6/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886556 | 0.88 | KDM4E (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2886906 | 0.86 | KDM4E (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2881087 | 0.85 | GABRP (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2882243 | 0.85 | RECQL (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2881605 | 0.80 | KDM4E (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2882557 | 0.79 | EGLN1 (0.58) | — | |
| SCHEMBL2881528 | 0.78 | RECQL (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2880588 | 0.77 | RECQL (0.54) | KDM4EALDH1A1ELANERXFP1F2 | |
| SCHEMBL14577430 | 0.76 | GABRP (0.77) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2881315 | 0.76 | RECQL (0.53) | GABRA2GABRB2ALDH1A1ELANERXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124489-B1 | THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN INC (US) | 2020-07-15 | — | — | EP | disclosed |
| EP-3124489-A1 | THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | Fibrogen, Inc. (US) | 2017-02-01 | — | — | EP | disclosed |
| EP-2016078-B1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN INC (US) | 2016-06-15 | — | — | EP | disclosed |
| US-7696223-B2 | [(2-bromo-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carbonyl)-amino]-acetic acid; modulates the stability and/or activity of hypoxia inducible factor (HIF) | FIBROGEN, INC. (US) | 2010-04-13 | — | — | US | disclosed |
| EP-2016078-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2009-01-21 | — | — | EP | disclosed |
| US-20080004309-A1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | FIBROGEN, INC. | 2008-01-03 | — | — | US | disclosed |
| WO-2007115315-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004309-A1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | HIF1AN, HIF1A, EGLN2 | GABRP 1302/4885GABRD 2732/4885GABRA1 2510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.