Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 11/20 | 0.40 |
| ▸ | NPY1R | P25929 | 6/20 | 0.40 |
| ▸ | NPY2R | P49146 | 4/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.40 |
| ▸ | ANPEP | P15144 | 2/20 | 0.39 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.39 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.39 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL28861125 | 0.94 | ALPI (0.41) | NPY4RNPY1RNPY2RNPY5RANPEP | |
| Tyrosine SCHEMBL28889524 | 0.93 | NPY4R (0.48) | NPY4RNPY1RNPY2RNPY5RANPEP | |
| Arginine SCHEMBL28861117 | 0.92 | ANPEP (0.37) | NPY4RNPY1RNPY2RNPY5RANPEP | |
| Arginine SCHEMBL27971714 | 0.91 | ALPI (0.44) | NPY4RNPY1RNPY2RNPY5RANPEP | |
| Tyrosine SCHEMBL27334545 | 0.90 | NPY4R (0.46) | NPY4RNPY1RNPY2RNPY5RTUBB4A | |
| Arginine SCHEMBL27448632 | 0.89 | NPY4R (0.38) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Arginine SCHEMBL27692294 | 0.89 | ANPEP (0.48) | NPY4RNPY1RNPY2RNPY5RANPEP | |
| Arginine SCHEMBL16323075 | 0.89 | ANPEP (0.48) | NPY4RNPY1RNPY2RNPY5RANPEP | |
| Arginine SCHEMBL29052768 | 0.88 | NPY4R (0.39) | NPY4RNPY1RNPY2RNPY5RSLC7A5 | |
| Arginine SCHEMBL5060815 | 0.88 | OTC (0.35) | NPY4RNPY1RNPY2RNPY5RTUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115028683-B | Pentapeptide compound and application thereof in preparation of medicines for treating liver fibrosis diseases | 陕西慧康生物科技有限责任公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-115028683-A | Pentapeptide compound and application thereof in preparation of medicine for treating hepatic fibrosis diseases | 陕西慧康生物科技有限责任公司 | 2022-09-09 | — | — | CN | disclosed |