Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | PRKX | P51817 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4406963 | 0.84 | ROCK2 (0.65) | ROCK2TGFBR1BMPR1AACVR1BACVRL1 | |
| SCHEMBL5320887 | 0.82 | ROCK2 (0.43) | ROCK2TGFBR1BMPR1AACVR1BACVRL1 | |
| SCHEMBL2888202 | 0.79 | ROCK1 (0.46) | ROCK2TGFBR1BMPR1AACVR1BACVRL1 | |
| SCHEMBL2888017 | 0.78 | ROCK2 (0.48) | ROCK2AXLPRKCIROCK1CYP3A4 | |
| SCHEMBL2887522 | 0.77 | ROCK2 (0.47) | ROCK2AXLPRKCIROCK1CYP3A4 | |
| SCHEMBL14028650 | 0.74 | ROCK1 (0.52) | ROCK2TGFBR1BMPR1AACVR1BACVRL1 | |
| SCHEMBL2881832 | 0.73 | ROCK2 (0.69) | ROCK2TGFBR1BMPR1AACVR1BACVRL1 | |
| SCHEMBL2882673 | 0.72 | ROCK2 (0.50) | ROCK2TGFBR1BMPR1AACVR1BACVRL1 | |
| SCHEMBL13593699 | 0.71 | ROCK1 (0.49) | ROCK2TGFBR1BMPR1AACVR1BACVRL1 | |
| SCHEMBL858953 | 0.70 | TNNI3K (0.52) | ROCK2TGFBR1BMPR1AACVR1BACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723347-B2 | Substituted phenylamino-pyrimidines | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-05-25 | — | — | US | disclosed |
| US-20080269268-A1 | Substituted Phenylamino-Pyrimidines | BAYER HEALTHCARE AG (DE) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269268-A1 | Substituted Phenylamino-Pyrimidines | TYMP, DPYD, HPRT1 | ROCK2 4593/4885TGFBR1 4251/4885BMPR1A 4355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.