Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 3/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 2/20 | 0.34 |
| ▸ | CDK8 | P49336 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.34 |
| ▸ | TEK | Q02763 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29615433 | 1.00 | PRMT5 (0.38) | PRMT5KITACVR1LRRK2PLA2G7 | |
| SCHEMBL29614180 | 0.82 | KIT (0.51) | KITLRRK2CSF1R | |
| SCHEMBL22918645 | 0.82 | KIT (0.51) | KITLRRK2CSF1R | |
| SCHEMBL29709020 | 0.82 | KIT (0.51) | KITLRRK2CSF1R | |
| SCHEMBL29615266 | 0.76 | GPR55 (0.48) | KIT | |
| SCHEMBL28862468 | 0.76 | GPR55 (0.48) | KIT | |
| SCHEMBL34464686 | 0.73 | CCNC (0.44) | PRMT5LRRK2CCNCCDK8NTRK1 | |
| SCHEMBL28862448 | 0.72 | MKNK1 (0.41) | KITCCNCCDK8CSF1R | |
| SCHEMBL29615564 | 0.72 | MKNK1 (0.41) | KITCCNCCDK8CSF1R | |
| SCHEMBL12936662 | 0.67 | EPHB4 (0.48) | ACVR1CCNCCDK8NTRK1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174293-A | 4- (imidazo [1,2-a ] pyridin-3-yl) -pyrimidine derivatives | 默克专利股份公司 | 2022-03-11 | — | — | CN | disclosed |