Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MYOC | Q99972 | 1/20 | 0.58 |
| ▸ | CDK8 | P49336 | 8/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29995637 | 0.90 | CDK8 (0.57) | CDK8CA12CA1CA2CA9 | |
| SCHEMBL28863208 | 0.90 | CDK8 (0.57) | CDK8CA12CA1CA2CA9 | |
| SCHEMBL14949667 | 0.88 | MAPT (0.51) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL14949664 | 0.88 | MAPT (0.51) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL1477788 | 0.84 | MAPT (0.55) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL2659166 | 0.83 | PIN1 (0.47) | MAPTRAB9AALDH1A1LMNAHTT | |
| SCHEMBL29806360 | 0.83 | PIN1 (0.47) | MAPTRAB9AALDH1A1LMNAHTT | |
| SCHEMBL12892581 | 0.83 | MAPT (0.54) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL11832409 | 0.81 | MEN1 (0.88) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL11821749 | 0.80 | MAPT (0.47) | MEN1NPC1MAPTRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197130-B | Aryl urea derivative and preparation method and application thereof | 安徽医科大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-115197130-A | Aryl urea derivative and preparation method and application thereof | 安徽医科大学 | 2022-10-18 | — | — | CN | disclosed |