Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 11/20 | 1.00 |
| ▸ | CDK7 | P50613 | 2/20 | 0.69 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.69 |
| ▸ | KDR | P35968 | 6/20 | 0.67 |
| ▸ | RAF1 | P04049 | 4/20 | 0.67 |
| ▸ | BRAF | P15056 | 2/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.62 |
| ▸ | KIT | P10721 | 2/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
| ▸ | CA7 | P43166 | 2/20 | 0.62 |
| ▸ | CA9 | Q16790 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | MUSK | O15146 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29996391 | 0.92 | CDK8 (1.00) | CDK8CDK7CDK6RETCCNC | |
| SCHEMBL28863217 | 0.92 | CDK8 (1.00) | CDK8CDK7CDK6RETCCNC | |
| SCHEMBL28863252 | 0.88 | CDK8 (1.00) | CDK8CDK7CDK6KDRBRAF | |
| SCHEMBL28863218 | 0.86 | CDK8 (0.83) | CDK8CDK7CDK6CA9EPHX2 | |
| SCHEMBL4344749 | 0.86 | RAF1 (0.78) | CDK8CDK7CDK6KDRRAF1 | |
| SCHEMBL5899269 | 0.85 | CDK8 (0.74) | CDK8CDK7CDK6KDRRAF1 | |
| SCHEMBL620425 | 0.84 | RAF1 (0.79) | CDK8CDK7CDK6KDRRAF1 | |
| SCHEMBL619479 | 0.84 | CDK8 (0.73) | CDK8CDK7CDK6KDRRAF1 | |
| SCHEMBL28863221 | 0.83 | CDK8 (0.84) | CDK8CDK7CDK6MEN1KMT2A | |
| SCHEMBL3174505 | 0.83 | CDK8 (0.71) | CDK8CDK7CDK6KDRRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197130-B | Aryl urea derivative and preparation method and application thereof | 安徽医科大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-115197130-A | Aryl urea derivative and preparation method and application thereof | 安徽医科大学 | 2022-10-18 | — | — | CN | disclosed |