Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 16/20 | 1.00 |
| ▸ | CDK7 | P50613 | 1/20 | 0.70 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.70 |
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | BRAF | P15056 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28863237 | 0.92 | CDK8 (1.00) | CDK8CDK7CDK6 | |
| SCHEMBL29996238 | 0.92 | CDK8 (1.00) | CDK8CDK7CDK6 | |
| SCHEMBL28863201 | 0.88 | CDK8 (1.00) | CDK8CDK7CDK6KDRBRAF | |
| SCHEMBL28863221 | 0.84 | CDK8 (0.84) | CDK8CDK7CDK6 | |
| SCHEMBL28863258 | 0.83 | CDK8 (0.79) | CDK8CDK7CDK6KDRBRAF | |
| SCHEMBL939171 | 0.82 | CDK8 (0.70) | CDK8CDK7CDK6KDRBRAF | |
| SCHEMBL28863266 | 0.82 | CDK8 (1.00) | CDK8CDK7CDK6KDRBRAF | |
| SCHEMBL28863205 | 0.82 | CDK8 (0.81) | CDK8CDK7CDK6 | |
| SCHEMBL28863200 | 0.81 | CDK8 (1.00) | CDK8CDK7CDK6 | |
| SCHEMBL28863240 | 0.80 | CDK8 (0.77) | CDK8CDK7CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197130-B | Aryl urea derivative and preparation method and application thereof | 安徽医科大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-115197130-A | Aryl urea derivative and preparation method and application thereof | 安徽医科大学 | 2022-10-18 | — | — | CN | disclosed |