Diflufenican

Diflufenican

SCHEMBL28864547

O=C(Nc1ccc(F)cc1F)c1cccnc1Oc1cccc(C(F)(F)F)c1.c1ccc(Oc2ccccc2)cc1

nearest known ligand 0.93

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.93
KDM4E B2RXH2 1/20 0.93
MEN1 O00255 1/20 0.93
CYP1A2 P05177 1/20 0.93
CYP2C19 P33261 1/20 0.93
NPSR1 Q6W5P4 1/20 0.93
P2RY1 P47900 9/20 0.72
EGFR P00533 1/20 0.54
S1PR3 Q99500 1/20 0.51
RXFP1 Q9HBX9 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diflufenican SCHEMBL22023 0.96 KMT2A (1.00) KMT2AKDM4EMEN1CYP1A2CYP2C19
Diflufenican SCHEMBL8536896 0.96 KMT2A (1.00) KMT2AKDM4EMEN1CYP1A2CYP2C19
Diflufenican SCHEMBL29373740 0.96 KMT2A (1.00) KMT2AKDM4EMEN1CYP1A2CYP2C19
Diflufenican SCHEMBL29549369 0.96 KMT2A (1.00) KMT2AKDM4EMEN1CYP1A2CYP2C19
Diflufenican SCHEMBL21295280 0.95 KMT2A (0.88) KMT2AKDM4EMEN1CYP1A2CYP2C19
Diflufenican SCHEMBL7534513 0.90 KMT2A (0.83) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL10968288 0.86 KDM4E (0.81) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL10970533 0.86 KMT2A (0.81) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL9616229 0.85 KMT2A (0.79) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL10968980 0.85 KDM4E (0.79) KMT2AKDM4EMEN1CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108552171-A Missible oil preparaton 胡茨曼澳大利亚股份有限公司 2018-09-21 CN disclosed