Diflufenican

Diflufenican

SCHEMBL8536896

O=C(Nc1ccc(F)cc1F)c1cccnc1Oc1cccc(C(F)(F)F)c1.O=C(Nc1ccc(F)cc1F)c1cccnc1Oc1cccc(C(F)(F)F)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 1.00
KDM4E B2RXH2 1/20 1.00
MEN1 O00255 1/20 1.00
CYP1A2 P05177 1/20 1.00
CYP2C19 P33261 1/20 1.00
NPSR1 Q6W5P4 1/20 1.00
P2RY1 P47900 14/20 0.77
EGFR P00533 1/20 0.57
S1PR3 Q99500 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diflufenican SCHEMBL22023 1.00 KMT2A (1.00) KMT2AKDM4EMEN1CYP1A2CYP2C19
Diflufenican SCHEMBL29549369 1.00 KMT2A (1.00) KMT2AKDM4EMEN1CYP1A2CYP2C19
Diflufenican SCHEMBL29373740 1.00 KMT2A (1.00) KMT2AKDM4EMEN1CYP1A2CYP2C19
Diflufenican SCHEMBL28864547 0.96 KMT2A (0.93) KMT2AKDM4EMEN1CYP1A2CYP2C19
Diflufenican SCHEMBL21295280 0.94 KMT2A (0.88) KMT2AKDM4EMEN1CYP1A2CYP2C19
Diflufenican SCHEMBL7534513 0.91 KMT2A (0.83) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL10968288 0.90 KDM4E (0.81) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL10970533 0.90 KMT2A (0.81) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL9616229 0.88 KMT2A (0.79) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL10968980 0.88 KDM4E (0.79) KMT2AKDM4EMEN1CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11197477-B2 Aqueous capsule suspension concentrates based on 2-[(2,4-dichlorophenyl)methyl]-4,4′-dimethyl-3-isoxazolidinone BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2021-12-14 US disclosed
EP-3787407-A1 AQUEOUS CAPSULE SUSPENSION CONCENTRATES CONTAINING A HERBICIDAL SAFENER AND A PESTICIDAL ACTIVE SUBSTANCE Bayer Aktiengesellschaft (DE) 2021-03-10 EP disclosed
EP-3697221-A1 AQUEOUS [2-(2,4-DICHLOROPHENYL)METHYL]-4,4-DIMETHYL-3-ISOXAZOLIDINONE-BASED SUSPENSION CONCENTRATES Bayer Aktiengesellschaft (DE) 2020-08-26 EP disclosed
EP-3402332-B1 AQUEOUS DISPERSIONS COMPRISING ACLONIFEN AND FLUFENACET BAYER CROPSCIENCE AG (DE) 2020-06-24 EP disclosed
US-20190200614-A1 AQUEOUS CAPSULE SUSPENSION CONCENTRATES BASED ON 2-[(2,4-DICHLOROPHENYL)METHYL]-4,4'-DIMETHYL-3-ISOXAZOLIDINONE FMC CORPORATION 2019-07-04 US disclosed
EP-3493677-A1 AQUEOUS 2-(2,4-DICHLOROPHENYL)METHYL -4,4-DIMETHYL-3-ISOXAZOLIDINONE-BASED CAPSULE SUSPENSION CONCENTRATES Bayer CropScience Aktiengesellschaft (DE) 2019-06-12 EP disclosed
WO-2019076744-A1 AQUEOUS [2-(2,4-DICHLOROPHENYL)METHYL]-4,4-DIMETHYL-3-ISOXAZOLIDINONE-BASED SUSPENSION CONCENTRATES BAYER AKTIENGESELLSCHAFT (DE) 2019-04-25 WO disclosed
US-20190053484-A1 SOLVENT-FREE FORMULATIONS OF LOW-MELTING ACTIVE INGREDIENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-02-21 US disclosed
US-20190021311-A1 AQUEOUS DISPERSIONS COMPRISING ACLONIFEN AND FLUFENACET BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-01-24 US disclosed
EP-3419418-A1 SOLVENT-FREE FORMULATIONS OF LOW-MELTING ACTIVE SUBSTANCES Bayer CropScience Aktiengesellschaft (DE) 2019-01-02 EP disclosed
EP-0575503-A1 HERBICIDAL PYRIDINE SULFONAMIDE E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-12-29 EP disclosed
EP-0574418-A1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS Hoechst Schering AgrEvo GmbH (DE) 1993-12-22 EP disclosed
WO-1992020684-A1 HERBICIDAL OXATRICYCLIC ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-11-26 WO disclosed
WO-1992015576-A1 HERBICIDAL PYRIDINE SULFONAMIDE E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-09-17 WO disclosed
WO-1992013845-A1 ARYL SULPHONYL UREA COMPOUNDS, A METHOD OF PREPARING THEM, AND THEIR USE AS HERBICIDES AND GROWTH REGULATORS HOECHST AKTIENGESELLSCHAFT (DE) 1992-08-20 WO disclosed
WO-1992013861-A1 HERBICIDAL BICYCLIC ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-08-20 WO disclosed
WO-1992010501-A1 HERBICIDAL ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-06-25 WO disclosed
WO-1992009587-A1 HERBICIDAL OXAZINE ETHERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-06-11 WO disclosed
WO-1992009578-A1 SUBSTITUTED FUSED HETEROCYCLIC HERBICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-06-11 WO disclosed
US-5041681-A Preparation of Substituted Cyclohexanetrione Herbicides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-08-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190200614-A1 AQUEOUS CAPSULE SUSPENSION CONCENTRATES BASED ON 2-[(2,4-DICHLOROPHENYL)METHYL]-4,4'-DIMETHYL-3-ISOXAZOLIDINONE ACMSD, DDT, CCND2 KMT2A 537/4885KDM4E 320/4885MEN1 3046/4885
US-20190053484-A1 SOLVENT-FREE FORMULATIONS OF LOW-MELTING ACTIVE INGREDIENTS CYP51A1, ABCG2, FASTKD5 KMT2A 3788/4885KDM4E 3939/4885MEN1 3605/4885
US-11197477-B2 Aqueous capsule suspension concentrates based on 2-[(2,4-dichlorophenyl)methyl]-4,4′-dimethyl-3-isoxazolidinone ACMSD, DDT, CCND2 KMT2A 541/4885KDM4E 320/4885MEN1 3058/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.