Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | YES1 | P07947 | 1/20 | 0.50 |
| ▸ | WNT1 | P04628 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29870028 | 1.00 | MET (0.60) | METMAP4K4FGFR2FGFR3CHEK1 | |
| SCHEMBL29870004 | 0.90 | FGFR2 (0.53) | METMAP4K4FGFR2FGFR3MAPK1 | |
| SCHEMBL30745147 | 0.86 | MET (0.62) | METFGFR2FGFR3MAPK1AURKB | |
| SCHEMBL28864744 | 0.86 | MET (0.62) | METFGFR2FGFR3MAPK1AURKB | |
| SCHEMBL14906657 | 0.82 | FGFR2 (0.52) | METFGFR2FGFR3MAPK1AURKB | |
| SCHEMBL29869630 | 0.82 | FGFR2 (0.52) | METFGFR2FGFR3MAPK1AURKB | |
| SCHEMBL29870086 | 0.82 | MET (0.46) | METFGFR2FGFR3MAPK1AURKB | |
| SCHEMBL16132972 | 0.81 | FGFR3 (0.74) | METFGFR2FGFR3FGFR1KDR | |
| SCHEMBL3587822 | 0.81 | MET (0.58) | METMAPK1AURKB | |
| SCHEMBL3256828 | 0.81 | FGFR3 (0.56) | METFGFR2FGFR3MAPK1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107312009-B | Quinoline compound, preparation method, intermediate, pharmaceutical composition and application thereof | 上海医药集团股份有限公司 | 2022-09-20 | — | — | CN | disclosed |