SCHEMBL28868237

SCHEMBL28868237

CC(=O)Nc1cc(O)c(C(=O)C=Cc2sc(-c3ccc(C(F)(F)F)cc3)nc2C(C)C)cc1C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.36
ALDH1A1 P00352 1/20 0.36
GAA P10253 1/20 0.36
PPARD Q03181 8/20 0.36
PPARA Q07869 7/20 0.36
PPARG P37231 6/20 0.36
FFAR1 O14842 3/20 0.35
ADORA3 P0DMS8 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
HSP90AA1 P07900 1/20 0.35
MAPT P10636 1/20 0.35
CRHBP P24387 1/20 0.35
KMT2A Q03164 1/20 0.35
CRHR2 Q13324 1/20 0.35
TP53 P04637 1/20 0.35
NR1H4 Q96RI1 1/20 0.35
TOP2A P11388 1/20 0.34
DYRK1A Q13627 1/20 0.33
PTGES O14684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28868233 1.00 NPC1 (0.36) NPC1ALDH1A1GAAPPARDPPARA
SCHEMBL30008188 1.00 NPC1 (0.36) NPC1ALDH1A1GAAPPARDPPARA
SCHEMBL28868239 0.89 PPARD (0.39) NPC1ALDH1A1GAAPPARDPPARA
SCHEMBL30008205 0.81 PPARD (0.49) PPARDPPARAPPARGFFAR1
SCHEMBL28868234 0.81 PPARD (0.49) PPARDPPARAPPARGFFAR1
SCHEMBL28868238 0.81 PPARD (0.49) PPARDPPARAPPARGFFAR1
SCHEMBL28868232 0.80 PPARD (0.45) NPC1ALDH1A1GAAPPARDPPARA
SCHEMBL30008095 0.80 PPARD (0.45) NPC1ALDH1A1GAAPPARDPPARA
SCHEMBL2463948 0.80 CYP1A1 (0.41) NPC1ALDH1A1GAAPPARDPPARA
SCHEMBL28868245 0.78 PPARD (0.43) NPC1ALDH1A1GAAPPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115215856-A Preparation method of PPAR delta agonist finadepa and intermediate thereof 沈阳药科大学 2022-10-21 CN claimed
CN-115215856-A Preparation method of PPAR delta agonist finadepa and intermediate thereof 沈阳药科大学 2022-10-21 CN disclosed