SCHEMBL2886858

SCHEMBL2886858

CCOC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)nc1C

nearest known ligand 0.80

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.80
MEN1 O00255 2/20 0.80
KMT2A Q03164 2/20 0.80
KDM4E B2RXH2 2/20 0.80
HSP90AA1 P07900 1/20 0.80
CRHBP P24387 1/20 0.80
CRHR2 Q13324 1/20 0.80
CDC7 O00311 6/20 0.72
DBF4 Q9UBU7 6/20 0.72
ALDH1A1 P00352 2/20 0.67
NPC1 O15118 1/20 0.67
GAA P10253 1/20 0.67
TRPM8 Q7Z2W7 5/20 0.58
PPARA Q07869 4/20 0.54
LMNA P02545 1/20 0.54
PPARG P37231 1/20 0.53
PPARD Q03181 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13046766 0.91 CDC7 (0.67) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL289583 0.89 KDM4E (0.65) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL28297323 0.89 MEN1 (0.64) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL4809764 0.89 MAPT (0.74) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL4801129 0.89 MAPT (0.78) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL8341363 0.89 MAPT (0.78) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL3368828 0.88 CDC7 (0.70) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL14109699 0.88 KDM4E (0.62) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL4804421 0.88 MAPT (0.76) MAPTMEN1KMT2AKDM4EHSP90AA1
SCHEMBL4484447 0.88 MAPT (0.76) MAPTMEN1KMT2AKDM4EHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 135 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116375663-A Febuxostat hapten, artificial antigen and application thereof 华南农业大学 2023-07-04 CN claimed
CN-116375663-B Febuxostat hapten, artificial antigen and application thereof 华南农业大学 2024-06-14 CN disclosed
US-20240166613-A1 PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME THE UNIVERSITY OF TOLEDO (US) 2024-05-23 US disclosed
CN-113189842-B Preparation method of color filter 江苏穿越光电科技有限公司 2024-05-17 CN disclosed
US-11897852-B2 Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same THE UNIVERSITY OF TOLEDO (US) 2024-02-13 US disclosed
CN-116375663-A Febuxostat hapten, artificial antigen and application thereof 华南农业大学 2023-07-04 CN disclosed
CN-113189842-A Preparation method of color filter 尚健 2021-07-30 CN disclosed
US-20210163431-A1 PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME THE UNIVERSITY OF TOLEDO (US) 2021-06-03 US disclosed
US-10941125-B2 Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same THE UNIVERSITY OF TOLEDO (US) 2021-03-09 US disclosed
EP-3124489-B1 THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS FIBROGEN INC (US) 2020-07-15 EP disclosed
EP-1324774-A2 USE OF A PPAR DELTA ACTIVATOR FOR TREATING INFLAMMATORY CONDITIONS GLAXO GROUP LIMITED (GB) 2003-07-09 EP disclosed
EP-1324773-A2 USE OF A PPAR DELTA ACTIVATOR IN THE TREATMENT OF DISEASES RELATED TO NO INHIBITION OR TNF INHIBITION GLAXO GROUP LIMITED (GB) 2003-07-09 EP disclosed
WO-2002092590-A1 FURAN AND THIOPHENE DERIVATIVES THAT ACTIVATE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS GLAXO GROUP LIMITED (GB) 2002-11-21 WO disclosed
WO-2002062774-A1 THIAZOLE DERIVATIVES FOR TREATING PPAR RELATED DISORDERS GLAXO GROUP LIMITED (GB) 2002-08-15 WO disclosed
WO-2002059098-A1 THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS GLAXO GROUP LIMITED (GB) 2002-08-01 WO disclosed
WO-2002050048-A1 THIA- AND OXAZOLES AND THEIR USE AS PPARS ACTIVATORS GLAXO GROUP LIMITED (GB) 2002-06-27 WO disclosed
WO-2002028434-A2 USE OF A PPAR DELTA ACTIVATOR FOR TREATING INFLAMMATORY CONDITIONS GLAXO GROUP LIMITED (GB) 2002-04-11 WO disclosed
WO-2002028433-A2 USE OF A PPAR DELTA ACTIVATOR IN THE TREATMENT OF DISEASES RELATED TO NO INHIBIT ION OR TNF INHIBITION GLAXO GROUP LIMITED (GB) 2002-04-11 WO disclosed
EP-1189895-A1 THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE GLAXO GROUP LIMITED (GB) 2002-03-27 EP disclosed
WO-2001000603-A1 THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE GLAXO GROUP LIMITED (GB) 2001-01-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240166613-A1 PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME PPARG, PPARA, PPARD MAPT 4707/4885MEN1 4748/4885KMT2A 3888/4885
US-10941125-B2 Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same PPARG, PPARA, PPARD MAPT 4708/4885MEN1 4755/4885KMT2A 3920/4885
US-11897852-B2 Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same PPARG, PPARA, PPARD MAPT 4708/4885MEN1 4755/4885KMT2A 3920/4885
US-20210163431-A1 PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME PPARG, PPARA, PPARD MAPT 4708/4885MEN1 4755/4885KMT2A 3920/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.