Histrelin

SCHEMBL28869225

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nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GNRHR

The experimentally established mechanism targets of Histrelin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	GNRHR known ✓	P30968	2/20	0.63

▸	ABCC2	Q92887	1/20	0.65

▸	PTGS1	P23219	1/20	0.59

▸	C5AR1	P21730	2/20	0.54

▸	APLNR	P35414	3/20	0.50

▸	KISS1R	Q969F8	1/20	0.49

▸	CXCR4	P61073	1/20	0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Histrelin SCHEMBL28130915	0.99	ABCC2 (0.66)	ABCC2GNRHRPTGS1C5AR1APLNR
Histrelin SCHEMBL27724983	0.98	GNRHR (0.65)	ABCC2GNRHRPTGS1C5AR1APLNR
Histrelin SCHEMBL19459949	0.98	ABCC2 (0.68)	ABCC2GNRHRPTGS1C5AR1APLNR
Histrelin SCHEMBL22288995	0.97	GNRHR (0.67)	ABCC2GNRHRPTGS1C5AR1APLNR
Histrelin SCHEMBL1650282	0.97	GNRHR (0.67)	ABCC2GNRHRPTGS1C5AR1APLNR
Leuprolide SCHEMBL27849465	0.94	ABCC2 (0.73)	ABCC2GNRHRPTGS1C5AR1APLNR
SCHEMBL28672062	0.93	GNRHR (0.61)	ABCC2GNRHRPTGS1C5AR1APLNR
Deslorelin SCHEMBL205614	0.93	ABCC2 (0.74)	ABCC2GNRHRPTGS1C5AR1APLNR
Acetic Acid SCHEMBL5166423	0.93	ABCC2 (0.74)	ABCC2GNRHRPTGS1C5AR1APLNR
Leuprolide SCHEMBL22288711	0.93	ABCC2 (0.74)	ABCC2GNRHRPTGS1C5AR1APLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-105451735-B	azetidine estrogen receptor modulators and uses thereof	西拉根制药公司	2019-01-11	—	—	CN	disclosed