Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1298062 | 0.84 | HRH3 (0.43) | BTKHRH3MAPK1DGAT1CHRNB2 | |
| SCHEMBL26064663 | 0.83 | BTK (0.41) | BTKHRH3MAPK1DGAT1CHRNB2 | |
| SCHEMBL26044135 | 0.83 | BTK (0.41) | BTKHRH3MAPK1DGAT1CHRNB2 | |
| SCHEMBL30886742 | 0.82 | BTK (0.40) | BTKHRH3MAPK1DGAT1CHRNB2 | |
| SCHEMBL29908992 | 0.82 | BTK (0.40) | BTKHRH3MAPK1DGAT1CHRNB2 | |
| SCHEMBL3643987 | 0.81 | CHRNB2 (0.48) | BTKHRH3MAPK1DGAT1CHRNB2 | |
| SCHEMBL4220147 | 0.81 | CHRNB2 (0.48) | BTKHRH3MAPK1DGAT1CHRNB2 | |
| SCHEMBL3643983 | 0.81 | CHRNB2 (0.48) | BTKHRH3MAPK1DGAT1CHRNB2 | |
| SCHEMBL30579733 | 0.80 | BTK (0.58) | BTKMAPK1GAAMEN1KMT2A | |
| SCHEMBL27420041 | 0.80 | BTK (0.39) | BTKHRH3MAPK1DGAT1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115362151-A | Aryl piperidines as monoacylglycerol lipase modulators | 詹森药业有限公司 | 2022-11-18 | — | — | CN | disclosed |
| CN-115362153-A | Aza spiro rings as monoacylglycerol lipase modulators | 詹森药业有限公司 | 2022-11-18 | — | — | CN | disclosed |
| CN-115335365-A | Aminocyclobutane as monoacylglycerol lipase modulators | 詹森药业有限公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-115066422-A | Monoacylglycerol lipase modulators | 詹森药业有限公司 | 2022-09-16 | — | — | CN | disclosed |