Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Aldicarb. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 7/20 | 0.38 |
| ▸ | NOS1 | P29475 | 7/20 | 0.38 |
| ▸ | NOS3 | P29474 | 6/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aldicarb SCHEMBL8778632 | 0.97 | TDP1 (0.63) | TDP1GSRTSHRALDH1A1HSD17B10 | |
| Aldicarb SCHEMBL20568578 | 0.86 | TDP1 (0.64) | TDP1GSRTSHRALDH1A1HSD17B10 | |
| Cystine SCHEMBL14645188 | 0.83 | TDP1 (0.68) | TDP1TSHRALDH1A1HSD17B10NOS2 | |
| Aldicarb SCHEMBL214691 | 0.83 | TDP1 (0.68) | TDP1TSHRALDH1A1HSD17B10NOS2 | |
| Aldicarb SCHEMBL21327721 | 0.80 | TDP1 (0.90) | TDP1TSHRALDH1A1HSD17B10 | |
| Aldicarb SCHEMBL7626286 | 0.78 | TDP1 (1.00) | TDP1TSHRALDH1A1HSD17B10 | |
| Aldicarb SCHEMBL3901576 | 0.77 | TDP1 (0.90) | TDP1TSHRALDH1A1HSD17B10 | |
| Aldicarb SCHEMBL9464143 | 0.77 | TDP1 (0.90) | TDP1TSHRALDH1A1HSD17B10 | |
| Aldicarb SCHEMBL9464151 | 0.77 | TDP1 (0.90) | TDP1TSHRALDH1A1HSD17B10 | |
| Aldicarb SCHEMBL9028720 | 0.77 | TDP1 (0.96) | TDP1TSHRALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1946416-A | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs with an extended therapeutic window | KENNETH S WARREN INST INC (US) | 2007-04-11 | — | — | CN | claimed |
| CN-1897960-A | Tissue protective cytokines for protection, restoration, and enhancement of responsive cells, tissues and organs with extended therapeutic window | KENNETH S WARREN INST INC (US) | 2007-01-17 | — | — | CN | claimed |
| US-7722858-B2 | Prevention and treatment of atherosclerosis by reducing carbamylation of LDL or the effects of carbamylated LDL | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2010-05-25 | — | — | US | disclosed |
| US-7476551-B2 | Diagnosing atherosclerosis risk by measuring carbamylated low density lipoprotein levels | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2009-01-13 | — | — | US | disclosed |
| WO-2007092625-A2 | PREVENTION AND TREATMENT OF ATHEROSCLEROSIS BY REDUCING CARBAMYLATION OF LDL OR THE EFFECTS OF CLDL | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2007-08-16 | — | — | WO | disclosed |
| US-20060183245-A1 | Prevention and treatment of atherosclerosis by reducing carbamylation of LDL or the effects of carbamylated LDL | BIOVENTURES, LLC | 2006-08-17 | — | — | US | disclosed |
| US-20030045004-A1 | Prevention and treatment of atherosclerosis by reducing carbamylation of LDL or the effects of carbamylated LDL | VETERANS AFFAIRS, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF | 2003-03-06 | — | — | US | disclosed |