Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Aldicarb. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aldicarb SCHEMBL9464143 | 1.00 | TDP1 (0.90) | TDP1ALDH1A1TSHRHSD17B10 | |
| Aldicarb SCHEMBL4061104 | 0.95 | TDP1 (1.00) | TDP1ALDH1A1TSHRHSD17B10 | |
| Aldicarb SCHEMBL7864399 | 0.95 | TDP1 (1.00) | TDP1ALDH1A1TSHRHSD17B10 | |
| Aldicarb SCHEMBL7626286 | 0.95 | TDP1 (1.00) | TDP1ALDH1A1TSHRHSD17B10 | |
| Aldicarb SCHEMBL9781 | 0.95 | TDP1 (1.00) | TDP1ALDH1A1TSHRHSD17B10 | |
| Aldicarb SCHEMBL7864397 | 0.95 | TDP1 (1.00) | TDP1ALDH1A1TSHRHSD17B10 | |
| Aldicarb SCHEMBL2788694 | 0.93 | TDP1 (0.90) | TDP1ALDH1A1TSHRHSD17B10 | |
| Aldicarb SCHEMBL21327721 | 0.93 | TDP1 (0.90) | TDP1ALDH1A1TSHRHSD17B10 | |
| Aldicarb SCHEMBL8462947 | 0.93 | TDP1 (0.96) | TDP1ALDH1A1TSHRHSD17B10 | |
| Aldicarb SCHEMBL5154132 | 0.93 | TDP1 (0.96) | TDP1ALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5200346-A | Aldicarb immunoassay by sulfone equivalents | ENSYS, INC. (US) | 1993-04-06 | — | — | US | disclosed |