SCHEMBL28873758

SCHEMBL28873758

Cc1cc(C(C)(C)C)c(O)c(C)c1Cc1ccnnn1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 6/20 0.52
CYP2C19 P33261 5/20 0.52
LMNA P02545 2/20 0.52
CYP3A4 P08684 2/20 0.52
HTR1A P08908 2/20 0.52
ADRA2A P08913 2/20 0.52
CYP1A2 P05177 2/20 0.52
CYP2D6 P10635 2/20 0.52
MEN1 O00255 1/20 0.52
CHRM2 P08172 1/20 0.52
CHRM4 P08173 1/20 0.52
CHRM5 P08912 1/20 0.52
CHRM1 P11229 1/20 0.52
TSHR P16473 1/20 0.52
ADRA2B P18089 1/20 0.52
ADRA2C P18825 1/20 0.52
ADRA1D P25100 1/20 0.52
HTR1D P28221 1/20 0.52
HTR1B P28222 1/20 0.52
HTR2A P28223 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28453026 0.79 ALDH1A1 (0.42) PTGS2CYP2C19LMNACYP3A4CYP1A2
SCHEMBL10814873 0.78 CYP2C19 (0.61) PTGS2CYP2C19LMNACYP3A4HTR1A
SCHEMBL9331710 0.75 CYP2C19 (0.58) PTGS2CYP2C19LMNACYP3A4HTR1A
SCHEMBL10482096 0.74 CYP2C19 (0.58) PTGS2CYP2C19LMNACYP3A4HTR1A
SCHEMBL10967992 0.74 CYP2C19 (0.57) PTGS2CYP2C19LMNACYP3A4HTR1A
SCHEMBL30415826 0.74 CYP2C19 (0.57) PTGS2CYP2C19LMNACYP3A4HTR1A
SCHEMBL10813956 0.72 CYP2C19 (0.56) PTGS2CYP2C19LMNACYP3A4HTR1A
SCHEMBL29000698 0.72 CYP2C19 (0.52) PTGS2CYP2C19LMNACYP3A4HTR1A
SCHEMBL30913173 0.70 CYP2C19 (0.52) PTGS2CYP2C19LMNACYP3A4HTR1A
SCHEMBL10000643 0.70 CYP2C19 (0.52) PTGS2CYP2C19LMNACYP3A4HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109890877-A Additive masterbatch composition based on semicrystalline polyolefins 陶氏环球技术有限责任公司 2019-06-14 CN disclosed