Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.46 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.43 |
| ▸ | TET3 | O43151 | 2/20 | 0.43 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL27687150 | 0.98 | SMN1; SMN2 (0.75) | SMN1; SMN2GPR84FFAR1FFAR4OR51E2 | |
| Malic Acid SCHEMBL193758 | 0.91 | SMN1; SMN2 (0.65) | SMN1; SMN2GPR84FFAR1FFAR4OR51E2 | |
| Malic Acid SCHEMBL17841691 | 0.90 | SMN1; SMN2 (0.58) | SMN1; SMN2GPR84FFAR1FFAR4SLC22A6 | |
| Cetostearyl Alcohol SCHEMBL28119456 | 0.90 | SMN1; SMN2 (0.58) | SMN1; SMN2GPR84FFAR1FFAR4SLC22A6 | |
| Cetyl Alcohol SCHEMBL14977021 | 0.90 | SMN1; SMN2 (0.58) | SMN1; SMN2GPR84FFAR1FFAR4SLC22A6 | |
| Decanol SCHEMBL29710016 | 0.90 | SMN1; SMN2 (0.58) | SMN1; SMN2GPR84FFAR1FFAR4SLC22A6 | |
| Malic Acid SCHEMBL28317492 | 0.87 | SMN1; SMN2 (0.83) | SMN1; SMN2OR51E2TET2TET3TET1 | |
| Malic Acid SCHEMBL27748793 | 0.87 | SMN1; SMN2 (0.83) | SMN1; SMN2OR51E2TET2TET3TET1 | |
| Isostearyl Alcohol SCHEMBL27806942 | 0.87 | SMN1; SMN2 (0.54) | SMN1; SMN2GPR84FFAR1FFAR4TET2 | |
| Malic Acid SCHEMBL98496 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115282342-A | Medical implant coating, preparation method thereof and medical implant | 南方医科大学南方医院 | 2022-11-04 | — | — | CN | claimed |
| CN-115282342-A | Medical implant coating, preparation method thereof and medical implant | 南方医科大学南方医院 | 2022-11-04 | — | — | CN | disclosed |
| CN-115282342-A | Medical implant coating, preparation method thereof and medical implant | 南方医科大学南方医院 | 2022-11-04 | — | — | CN | disclosed |