Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.50 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.48 |
| ▸ | KDM4A | O75164 | 2/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.48 |
| ▸ | TET3 | O43151 | 2/20 | 0.48 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.42 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL27687150 | 0.93 | SMN1; SMN2 (0.75) | SMN1; SMN2GPR84FFAR1FFAR4TET2 | |
| Malic Acid SCHEMBL28874241 | 0.91 | SMN1; SMN2 (0.71) | SMN1; SMN2GPR84FFAR1FFAR4TET2 | |
| Malic Acid SCHEMBL28105083 | 0.89 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL4814892 | 0.89 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL11436449 | 0.86 | SMN1; SMN2 (0.79) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL7895521 | 0.84 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Adipic Acid SCHEMBL2019308 | 0.84 | SMN1; SMN2 (0.75) | SMN1; SMN2GPR84FFAR1FFAR4TET2 | |
| Malic Acid SCHEMBL27748793 | 0.84 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Malic Acid SCHEMBL28317492 | 0.84 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2KDM4AKDM4CKDM2A | |
| Cadaverine Tartrate SCHEMBL7419325 | 0.82 | SMN1; SMN2 (0.71) | SMN1; SMN2TET2KDM4AKDM4CKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3897452-B1 | RESORBABLE NONWOVEN POUCHES FOR MEDICAL DEVICE IMPLANTS | TEPHA INC (US) | 2024-07-03 | — | — | EP | claimed |
| US-11896734-B2 | Surgical mesh implants containing poly(butylene succinate) and copolymers thereof | TEPHA, INC. (US) | 2024-02-13 | — | — | US | claimed |
| US-11878087-B2 | Oriented implants containing poly(butylene succinate) and copolymer, and methods of use thereof | TEPHA, INC. (US) | 2024-01-23 | — | — | US | claimed |
| US-11786632-B2 | Hernia repair, breast reconstruction and sling devices containing poly(butylene succinate) and copolymers thereof | TEPHA, INC. (US) | 2023-10-17 | — | — | US | claimed |
| US-20230201610-A1 | RESORBABLE NONWOVEN POUCHES FOR MEDICAL DEVICE IMPLANTS | TEPHA, INC. (US) | 2023-06-29 | — | — | US | claimed |
| US-11612754-B2 | Resorbable nonwoven pouches for medical device implants | TEPHA, INC. (US) | 2023-03-28 | — | — | US | claimed |
| EP-4021518-A1 | MEDICAL DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF | Tepha, Inc. (US) | 2022-07-06 | — | — | EP | claimed |
| US-20220202988-A1 | YARNS AND FIBERS OF POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF, AND METHODS OF USE THEREOF | TEPHA, INC. (US) | 2022-06-30 | — | — | US | claimed |
| CN-114630931-A | Medical devices comprising poly (butylene succinate) and copolymers thereof | 特法公司 | 2022-06-14 | — | — | CN | claimed |
| EP-3897452-A1 | RESORBABLE NONWOVEN POUCHES FOR MEDICAL DEVICE IMPLANTS | Tepha, Inc. (US) | 2021-10-27 | — | — | EP | claimed |
| WO-2021042044-A1 | MEDICAL DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF | TEPHA, INC. (US) | 2021-03-04 | — | — | WO | claimed |
| EP-3758764-A1 | MEDICAL DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF | Tepha, Inc. (US) | 2021-01-06 | — | — | EP | claimed |
| US-20200197712-A1 | RESORBABLE NONWOVEN POUCHES FOR MEDICAL DEVICE IMPLANTS | TEPHA, INC. | 2020-06-25 | — | — | US | claimed |
| WO-2020131172-A1 | RESORBABLE NONWOVEN POUCHES FOR MEDICAL DEVICE IMPLANTS | TEPHA, INC. (US) | 2020-06-25 | — | — | WO | claimed |
| US-20190269815-A1 | YARNS AND FIBERS OF POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF, AND METHODS OF USE THEROF | TEPHA, INC. | 2019-09-05 | — | — | US | claimed |
| US-20190269822-A1 | HERNIA REPAIR, BREAST RECONSTRUCTION AND SLING DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF | TEPHA, INC. | 2019-09-05 | — | — | US | claimed |
| US-20190269816-A1 | ORIENTED IMPLANTS CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMER, AND METHODS OF USE THEREOF | TEPHA, INC. | 2019-09-05 | — | — | US | claimed |
| US-20190269817-A1 | SURGIAL MESH IMPLANTS CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF | TEPHA, INC. | 2019-09-05 | — | — | US | claimed |
| US-20240238077-A1 | NIPPLE RECONSTRUCTION IMPLANT | TEPHA, INC. (US) | 2024-07-18 | — | — | US | disclosed |
| EP-1882712-A1 | POLYESTER DERIVED FROM BIOMASS RESOURCES AND METHOD FOR PRODUCTION THEREOF | Mitsubishi Chemical Corporation (JP) | 2008-01-30 | — | — | EP | disclosed |