Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 15/20 | 0.57 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.57 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | FECH | P22830 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | MELK | Q14680 | 1/20 | 0.46 |
| ▸ | MYLK3 | Q32MK0 | 1/20 | 0.46 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.46 |
| ▸ | TP53RK | Q96S44 | 1/20 | 0.46 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.45 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 6/20 | 0.44 |
| ▸ | ATR | Q13535 | 6/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL995325 | 0.86 | PIK3CD (0.62) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL927455 | 0.83 | MTOR (0.59) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL929868 | 0.82 | MTOR (0.56) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL929764 | 0.80 | MTOR (0.62) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL928291 | 0.79 | MTOR (0.67) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3180379 | 0.79 | MTOR (0.62) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3180388 | 0.79 | MTOR (0.62) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL929486 | 0.78 | MTOR (0.55) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL929485 | 0.78 | MTOR (0.55) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2887432 | 0.78 | MTOR (0.51) | MTORPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056558-A1 | 1,3-DIHYDRO-IMIDAZO[4,5-C]QUINOLIN-2-ONES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056558-A1 | 1,3-DIHYDRO-IMIDAZO[4,5-C]QUINOLIN-2-ONES AS LIPID KINASE INHIBITORS | PDPK1, PI4KA, PIP4K2A | MTOR 89/4885PIK3CD 9/4885PIK3CA 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.