Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.62 |
| ▸ | MTOR | P42345 | 13/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.62 |
| ▸ | ATM | Q13315 | 6/20 | 0.47 |
| ▸ | ATR | Q13535 | 6/20 | 0.47 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.47 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | NEK2 | P51955 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2887430 | 0.86 | MTOR (0.57) | PIK3CDMTORPIK3CAPIK3CBPIK3CG | |
| SCHEMBL994354 | 0.85 | MTOR (0.61) | PIK3CDMTORPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14844887 | 0.83 | MTOR (0.66) | PIK3CDMTORPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3515260 | 0.81 | PIK3CD (0.57) | PIK3CDMTORPIK3CAPIK3CBPIK3CG | |
| SCHEMBL927455 | 0.81 | MTOR (0.59) | PIK3CDMTORPIK3CAPIK3CBPIK3CG | |
| SCHEMBL927144 | 0.80 | PIK3CA (0.72) | PIK3CDMTORPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3180388 | 0.79 | MTOR (0.62) | PIK3CDMTORPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3180379 | 0.79 | MTOR (0.62) | PIK3CDMTORPIK3CAPIK3CBPIK3CG | |
| SCHEMBL929764 | 0.79 | MTOR (0.62) | PIK3CDMTORPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14872899 | 0.78 | MTOR (0.51) | PIK3CDMTORPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2270008-B1 | 8-heteroaryl-3-alkyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-ones as PI-3 kinases inhibitors | NOVARTIS AG (CH) | 2012-10-03 | — | — | EP | disclosed |
| EP-2292617-B1 | 1,3-dihydro-imidazo[4,5-c]quinolin-2-ones as lipid kinase and/or pi3 kinase inhibitors | NOVARTIS AG (CH) | 2012-07-11 | — | — | EP | disclosed |
| EP-1888578-B9 | 2-METHYL-2-[4-(3-METHYL-2-OXO-8-QUINOLIN-3-YL-2,3-DIHYDRO-IMIDAZO [4,5-C] QUINOLINYL)-PHENYL]PROPIONITRILE AS LIPID KINASE INHIBITOR | NOVARTIS AG (CH) | 2012-04-25 | — | — | EP | disclosed |
| EP-1888578-B1 | 2-METHYL-2-[4-(3-METHYL-2-OXO-8-QUINOLIN-3-YL-2,3-DIHYDRO-IMIDAZO [4,5-C] QUINOLINYL)-PHENYL]PROPIONITRILE AS LIPID KINASE INHIBITOR | NOVARTIS AG (CH) | 2011-11-30 | — | — | EP | disclosed |
| EP-2292617-A1 | 1,3-dihydro-imidazo[4,5-c]quinolin-2-ones as lipid kinase and/or pi3 kinase inhibitors | Novartis AG (CH) | 2011-03-09 | — | — | EP | disclosed |
| EP-2270008-A1 | 1,3-dihydro-imidazo[4,5-c]quinolin-2-ones as lipid kinase and/or pi3 kinases inhibitors | Novartis AG (CH) | 2011-01-05 | — | — | EP | disclosed |