Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.63 |
| ▸ | JAK1 | P23458 | 8/20 | 0.63 |
| ▸ | JAK2 | O60674 | 6/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28876023 | 0.91 | JAK1 (0.61) | JAK3JAK1JAK2 | |
| SCHEMBL28875988 | 0.90 | JAK3 (0.64) | JAK3JAK1JAK2 | |
| SCHEMBL28876012 | 0.84 | JAK3 (0.63) | JAK3JAK1JAK2SLC6A3KCNH2 | |
| Morpholine SCHEMBL28329000 | 0.83 | JAK3 (0.73) | JAK3JAK1JAK2EGFR | |
| SCHEMBL28876013 | 0.81 | JAK1 (0.62) | JAK3JAK1JAK2 | |
| SCHEMBL28385550 | 0.79 | EGFR (0.61) | SLC6A3KCNH2TAAR1EGFR | |
| SCHEMBL28394043 | 0.78 | EGFR (0.47) | SLC6A3KCNH2TAAR1EGFR | |
| SCHEMBL21751160 | 0.78 | CSF1R (0.47) | JAK3SLC6A3KCNH2TAAR1EGFR | |
| SCHEMBL29813686 | 0.77 | JAK3 (1.00) | JAK3JAK1JAK2EGFR | |
| SCHEMBL28875990 | 0.77 | JAK3 (1.00) | JAK3JAK1JAK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330484-B | Substituted phenyl pyrimidine derivative as JAK kinase inhibitor or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |