Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 1.00 |
| ▸ | JAK3 | P52333 | 7/20 | 1.00 |
| ▸ | JAK1 | P23458 | 6/20 | 1.00 |
| ▸ | TYK2 | P29597 | 3/20 | 1.00 |
| ▸ | EGFR | P00533 | 1/20 | 0.73 |
| ▸ | BTK | Q06187 | 5/20 | 0.71 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.61 |
| ▸ | TTK | P33981 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29813541 | 1.00 | JAK2 (1.00) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL17071413 | 0.94 | JAK2 (0.88) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL28875992 | 0.90 | JAK2 (1.00) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL29813742 | 0.90 | JAK2 (1.00) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL29813581 | 0.89 | JAK2 (1.00) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL28875975 | 0.89 | JAK2 (1.00) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL15637731 | 0.89 | JAK2 (0.80) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL17071335 | 0.88 | JAK3 (0.79) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL17071334 | 0.88 | JAK3 (0.79) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL4379023 | 0.88 | JAK2 (0.80) | JAK2JAK3JAK1TYK2MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330484-B | Substituted phenyl pyrimidine derivative as JAK kinase inhibitor or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |