Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.65 |
| ▸ | JAK1 | P23458 | 12/20 | 0.65 |
| ▸ | JAK2 | O60674 | 11/20 | 0.65 |
| ▸ | TYK2 | P29597 | 3/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28876041 | 0.92 | JAK3 (0.77) | JAK3JAK1JAK2TYK2PIK3CB | |
| SCHEMBL29813697 | 0.88 | JAK3 (0.84) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28876030 | 0.88 | JAK3 (0.84) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28876015 | 0.87 | JAK3 (0.56) | JAK3JAK1JAK2TYK2LMNA | |
| Morpholine SCHEMBL28329001 | 0.82 | JAK3 (0.66) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28876037 | 0.79 | JAK3 (1.00) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL29813592 | 0.79 | JAK3 (1.00) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28328997 | 0.78 | JAK3 (0.56) | JAK3JAK1JAK2TYK2PIK3CB | |
| SCHEMBL28875985 | 0.77 | JAK3 (0.58) | JAK3JAK1JAK2TYK2LMNA | |
| SCHEMBL29813539 | 0.76 | JAK2 (0.71) | JAK3JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330484-B | Substituted phenyl pyrimidine derivative as JAK kinase inhibitor or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |