Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.56 |
| ▸ | JAK2 | O60674 | 8/20 | 0.56 |
| ▸ | JAK1 | P23458 | 7/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 4/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28875985 | 0.91 | JAK3 (0.58) | JAK3JAK2JAK1PLK4TYK2 | |
| SCHEMBL29813539 | 0.88 | JAK2 (0.71) | JAK3JAK2JAK1PLK4TYK2 | |
| SCHEMBL28876010 | 0.88 | JAK2 (0.71) | JAK3JAK2JAK1PLK4TYK2 | |
| SCHEMBL28876033 | 0.87 | JAK3 (0.65) | JAK3JAK2JAK1TYK2LMNA | |
| Morpholine SCHEMBL28328992 | 0.83 | JAK3 (0.53) | JAK3JAK2JAK1PLK4TYK2 | |
| SCHEMBL29813737 | 0.79 | JAK3 (0.72) | JAK3JAK2JAK1PLK4TYK2 | |
| SCHEMBL28875981 | 0.79 | JAK3 (0.72) | JAK3JAK2JAK1PLK4TYK2 | |
| SCHEMBL28876041 | 0.79 | JAK3 (0.77) | JAK3JAK2JAK1TYK2LMNA | |
| SCHEMBL28328991 | 0.78 | JAK3 (0.48) | JAK3JAK2JAK1PLK4TYK2 | |
| SCHEMBL13859449 | 0.77 | JAK3 (0.77) | JAK3JAK2JAK1PLK4TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110330484-B | Substituted phenyl pyrimidine derivative as JAK kinase inhibitor or pharmaceutically acceptable salt thereof, preparation method and application | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |