Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 7/20 | 0.66 |
| ▸ | DCUN1D1 | Q96GG9 | 6/20 | 0.57 |
| ▸ | UBE2M | P61081 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18458071 | 0.79 | IDH2 (1.00) | IDH2 | |
| SCHEMBL11417956 | 0.78 | EPHX2 (0.87) | DCUN1D1UBE2MMEN1KMT2AEPHX2 | |
| SCHEMBL28876334 | 0.77 | IDH2 (0.55) | IDH2DCUN1D1UBE2MMEN1KMT2A | |
| SCHEMBL6813295 | 0.76 | LMNA (0.58) | MEN1KMT2AMAPTHTTKDM4E | |
| SCHEMBL2472548 | 0.75 | MEN1 (0.70) | MEN1KMT2AMAPTPOLBCCR2 | |
| SCHEMBL7154486 | 0.75 | LMNA (0.63) | MEN1KMT2AMAPTHTTPOLB | |
| SCHEMBL4282039 | 0.73 | EPHX2 (0.79) | DCUN1D1UBE2MMEN1KMT2AEPHX2 | |
| SCHEMBL4282043 | 0.73 | EPHX2 (0.79) | DCUN1D1UBE2MMEN1KMT2AEPHX2 | |
| SCHEMBL23591726 | 0.73 | IDH2 (0.53) | IDH2MEN1KMT2AEPHX2MAPT | |
| SCHEMBL2752512 | 0.73 | EPHX2 (0.97) | DCUN1D1UBE2MMEN1KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106810512-B | IDH2 mutant inhibitor and application thereof | 江苏省中医药研究院 | 2019-09-10 | — | — | CN | disclosed |