Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.40 |
| ▸ | MTOR | P42345 | 5/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.33 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.33 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.33 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | GCKR | Q14397 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17340556 | 0.82 | CDK4 (0.43) | PIK3CAMTORPIK3R1CHRNB2CHRNA4 | |
| SCHEMBL4549816 | 0.82 | CDK4 (0.43) | PIK3CAMTORPIK3R1CHRNB2CHRNA4 | |
| SCHEMBL28076420 | 0.82 | PIK3CA (0.40) | PIK3CAMTORPIK3R1CHRNB2CHRNA4 | |
| SCHEMBL21698724 | 0.82 | CDK4 (0.43) | PIK3CAMTORPIK3R1CHRNB2CHRNA4 | |
| SCHEMBL23103817 | 0.79 | ADORA2A (0.49) | PIK3CAMTORPIK3R1CHRNB2CHRNA4 | |
| SCHEMBL23104529 | 0.79 | ADORA2A (0.49) | PIK3CAMTORPIK3R1CHRNB2CHRNA4 | |
| SCHEMBL23104568 | 0.79 | ADORA2A (0.49) | PIK3CAMTORPIK3R1CHRNB2CHRNA4 | |
| SCHEMBL28876546 | 0.78 | PIK3CA (0.37) | PIK3CAMTORPIK3R1CHRNB2CHRNA4 | |
| SCHEMBL521049 | 0.77 | PIK3CA (0.56) | PIK3CAMTORPIK3R1POLBAKT1 | |
| SCHEMBL23089186 | 0.76 | MAP4K1 (0.41) | PIK3CAMTORPIK3R1CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114945366-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2022-08-26 | — | — | CN | disclosed |