Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 4/20 | 0.40 |
| ▸ | GAK | O14976 | 3/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21698724 | 1.00 | CDK4 (0.43) | CDK4CCND1CDK6MAPTRAB9A | |
| SCHEMBL17340556 | 1.00 | CDK4 (0.43) | CDK4CCND1CDK6MAPTRAB9A | |
| SCHEMBL2722889 | 0.83 | MAPT (0.58) | CDK4CCND1CDK6MAPTRAB9A | |
| SCHEMBL4825445 | 0.83 | MAPT (0.58) | CDK4CCND1CDK6MAPTRAB9A | |
| SCHEMBL28876591 | 0.82 | PIK3CA (0.40) | CDK4CCND1CDK6MAPTPIK3CA | |
| SCHEMBL28076420 | 0.82 | PIK3CA (0.40) | PIK3CAMTORPIK3R1CHRNB2CHRNA4 | |
| SCHEMBL28876546 | 0.81 | PIK3CA (0.37) | MAPTPIK3CAMTORPIK3R1CHRNB2 | |
| SCHEMBL14167561 | 0.81 | MAPT (0.46) | CDK4CCND1CDK6MAPTRAB9A | |
| SCHEMBL12236694 | 0.81 | MAPT (0.46) | CDK4CCND1CDK6MAPTRAB9A | |
| SCHEMBL23104529 | 0.79 | ADORA2A (0.49) | PIK3CAMTORPIK3R1LRRK2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061156-A1 | CDK INHIBITORS | TAVARES FRANCIS X (US) | 2012-05-10 | — | — | WO | disclosed |