SCHEMBL28877708

SCHEMBL28877708

CC1(C)CC(=O)C2=C(C1)OC(N)=C(C#N)C2c1cccc(C#N)c1

nearest known ligand 0.78

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 13/20 0.78
TSHR P16473 2/20 0.78
GRIA3 P42263 1/20 0.73
GRIA4 P48058 1/20 0.73
POLB P06746 3/20 0.66
KMT2A Q03164 7/20 0.66
MEN1 O00255 6/20 0.63
MAPT P10636 2/20 0.63
L3MBTL1 Q9Y468 1/20 0.63
USP2 O75604 3/20 0.62
HPGD P15428 2/20 0.62
PKM P14618 1/20 0.62
SMN1; SMN2 Q16637 2/20 0.61
KDM4E B2RXH2 3/20 0.59
CYP3A4 P08684 1/20 0.59
CYP2C9 P11712 1/20 0.59
CYP2C19 P33261 1/20 0.59
TDP1 Q9NUW8 1/20 0.59
TP53 P04637 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28664509 0.89 ALDH1A1 (0.78) ALDH1A1TSHRGRIA3GRIA4POLB
SCHEMBL28649237 0.89 ALDH1A1 (0.78) ALDH1A1TSHRGRIA3GRIA4POLB
SCHEMBL6707595 0.88 ALDH1A1 (0.77) ALDH1A1TSHRGRIA3GRIA4POLB
SCHEMBL28325540 0.88 ALDH1A1 (0.77) ALDH1A1TSHRGRIA3GRIA4POLB
SCHEMBL6705731 0.88 ALDH1A1 (0.77) ALDH1A1TSHRGRIA3GRIA4POLB
SCHEMBL6705746 0.88 ALDH1A1 (1.00) ALDH1A1TSHRGRIA3GRIA4POLB
SCHEMBL6705949 0.87 ALDH1A1 (0.81) ALDH1A1TSHRGRIA3GRIA4POLB
SCHEMBL3000625 0.87 ALDH1A1 (0.77) ALDH1A1TSHRGRIA3GRIA4POLB
SCHEMBL6705768 0.87 ALDH1A1 (0.78) ALDH1A1TSHRGRIA3GRIA4POLB
SCHEMBL28798326 0.86 ALDH1A1 (0.72) ALDH1A1TSHRGRIA3GRIA4POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110420206-B Application of benzopyran compounds in preparing anti-Hantaan virus medicines 中国人民解放军第四军医大学 2022-07-01 CN disclosed
CN-110420206-A Benzopyrans compounds are used to prepare the application of anti-hantaan virus drug 4TH MILITARY MEDICAL UNIV CHINESE PLA 2019-11-08 CN disclosed