Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 18/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.68 |
| ▸ | PDE4A | P27815 | 11/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.68 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6286337 | 1.00 | PDE4D (0.68) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL5875876 | 0.89 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL2888335 | 0.89 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL6489896 | 0.87 | PDE4D (0.61) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL6479899 | 0.86 | PDE4D (0.74) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL6479903 | 0.84 | PDE4D (0.74) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL6485190 | 0.84 | PDE4D (0.71) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL5553386 | 0.84 | PDE4D (0.78) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL6485199 | 0.84 | PDE4D (0.71) | PDE4DPDE4BPDE4APDE4CPDE7B | |
| SCHEMBL6256486 | 0.83 | PDE7B (0.85) | PDE4DPDE4BPDE4APDE4CPDE7B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006528229-A | — | — | 2006-12-14 | — | — | JP | claimed |
| US-20060094723-A1 | Composition comprising a pde4 inhibitor and a pde5 inhibitor | NYCOMED GMBH (DE) | 2006-05-04 | — | — | US | claimed |
| EP-1628682-A2 | COMPOSITION COMPRISING A PDE4 INHIBITOR AND A PDE5 INHIBITOR | ALTANA Pharma AG (DE) | 2006-03-01 | — | — | EP | claimed |
| EP-1587512-A2 | PDE4 INHIBITORS FOR THE TREATMENT OF NEOPLASMS OF LYMPHOID CELLS | ALTANA Pharma AG (DE) | 2005-10-26 | — | — | EP | claimed |
| US-6953853-B2 | Phospholipase inhbitors; antiinflammatory agents; respiratory system disorders | ALTANA PHARMA AG (DE) | 2005-10-11 | — | — | US | claimed |
| WO-2005023253-A1 | USE OF PDE4 INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS | ALTANA PHARMA AG (DE) | 2005-03-17 | — | — | WO | claimed |
| WO-2004103407-A2 | COMPOSITION COMPRISING A PDE4 INHIBITOR AND A PDE5 INHIBITOR | ALTANA PHARMA AG (DE) | 2004-12-02 | — | — | WO | claimed |
| WO-2004098633-A1 | COMPOSITION COMPRISING A PDE-4 INHIBITOR AND A TNF ALPHA ANTAGONIST | ALTANA PHARMA AG (DE) | 2004-11-18 | — | — | WO | claimed |
| WO-2004098605-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A PDE4 INHIBITOR AND IL-1 TRAP | ALTANA PHARMA AG (DE) | 2004-11-18 | — | — | WO | claimed |
| WO-2004098606-A1 | COMPOSITION COMPRISING A PDE4 INHIBITOR AND SHUIL-1R II | ALTANA PHARMA AG (DE) | 2004-11-18 | — | — | WO | claimed |
| WO-2004098578-A2 | COMPOSITION COMPRISING A PDE4 INHIBITOR AND A TNF-ALFA ANTAGONIST SELECTED FROM INFLIXIMAB, ADALIMUMAB, CDP870 AND CDP517 | ALTANA PHARMA AG (DE) | 2004-11-18 | — | — | WO | claimed |
| WO-2004062671-A2 | PDE4 INHIBITORS FOR THE TREATMENT OF NEOPLASMS OF LYMPHOID CELLS | ALTANA PHARMA AG (DE) | 2004-07-29 | — | — | WO | claimed |
| US-20040067946-A1 | Phthalatyinone-piperidino-derivatives as pde4 inhibitors | TAKEDA GMBH (DE) | 2004-04-08 | — | — | US | claimed |
| EP-1362044-A1 | PHTHALAZINONE-PIPERIDINO-DERIVATIVES AS PDE4 INHIBITORS | ALTANA Pharma AG (DE) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064584-A1 | PHTHALAYINONE-PIPERIDINO-DERIVATIVES AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2002-08-22 | — | — | WO | claimed |
| US-7776893-B2 | Use of PDE4 inhibitors for the treatment of diabetes mellitus | NYCOMED GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| US-7531540-B2 | Phthalazinone-piperidino-derivatives as PDE4 inhibitors | NYCOMED GMBH (DE) | 2009-05-12 | — | — | US | disclosed |
| US-20040067946-A1 | Phthalatyinone-piperidino-derivatives as pde4 inhibitors | TAKEDA GMBH (DE) | 2004-04-08 | — | — | US | disclosed |
| EP-1362044-A1 | PHTHALAZINONE-PIPERIDINO-DERIVATIVES AS PDE4 INHIBITORS | ALTANA Pharma AG (DE) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002064584-A1 | PHTHALAYINONE-PIPERIDINO-DERIVATIVES AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094723-A1 | Composition comprising a pde4 inhibitor and a pde5 inhibitor | PDE5A, PDE12, PDE4A | PDE4D 9/4885PDE4B 4/4885PDE4A 3/4885 |
| US-20040067946-A1 | Phthalatyinone-piperidino-derivatives as pde4 inhibitors | PDE4A, PDE4B, PDE5A | PDE4D 9/4885PDE4B 2/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.