Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 13/20 | 0.38 |
| ▸ | LPL | P06858 | 12/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | F11 | P03951 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14230881 | 0.81 | LPL (0.41) | LIPGLPLROCK1F11ESR2 | |
| SCHEMBL29175433 | 0.79 | ROCK1 (0.33) | LIPGLPLROCK1IRAK4 | |
| SCHEMBL25513578 | 0.76 | IRAK4 (0.36) | IRAK4 | |
| SCHEMBL9983507 | 0.75 | AKR1B1 (0.41) | IRAK4CA1CA2 | |
| SCHEMBL30785273 | 0.75 | IRAK4 (0.35) | IRAK4 | |
| SCHEMBL28877912 | 0.75 | IRAK4 (0.35) | IRAK4 | |
| SCHEMBL31430390 | 0.73 | HDAC3 (0.36) | LIPGLPLROCK1 | |
| SCHEMBL14792954 | 0.72 | LPL (0.39) | LIPGLPLROCK1F11IRAK4 | |
| SCHEMBL19585596 | 0.72 | ROCK1 (0.35) | LIPGLPLROCK1F11IRAK4 | |
| SCHEMBL483159 | 0.71 | LPL (0.43) | LIPGLPLROCK1F11IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022206730-A1 | PYRIMIDOPYRAZINE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-06 | — | — | WO | disclosed |
| CN-115141202-A | Pyrimidopyrazinone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-04 | — | — | CN | disclosed |