Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6101289 | 0.88 | HDAC8 (0.40) | HDAC8LMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL16931450 | 0.82 | KDM4E (0.38) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL31394878 | 0.81 | HDAC8 (0.40) | HDAC8LMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL1637329 | 0.79 | HDAC8 (0.39) | HDAC8HTTMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL31394603 | 0.76 | HDAC8 (0.38) | HDAC8LMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL16569404 | 0.76 | HDAC8 (0.40) | HDAC8LMNAHTTMAPTMEN1 | |
| SCHEMBL16931118 | 0.76 | MAPT (0.45) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL26983072 | 0.76 | HDAC8 (0.38) | HDAC8SMN1; SMN2PPARARAB9ABACE1 | |
| SCHEMBL23320737 | 0.74 | HDAC8 (0.47) | HDAC8HTTMAPTGAAHDAC6 | |
| SCHEMBL146444 | 0.73 | HDAC8 (0.38) | HDAC8HTTMAPTRAB9ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022206730-A1 | PYRIMIDOPYRAZINE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-06 | — | — | WO | disclosed |
| CN-115141202-A | Pyrimidopyrazinone compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-04 | — | — | CN | disclosed |