Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28877950 | 0.88 | HDAC8 (0.43) | HDAC8HTR2AHTR2CBACE1LMNA | |
| SCHEMBL31394878 | 0.84 | HDAC8 (0.40) | HDAC8HTR2AHTR2CBACE1LMNA | |
| SCHEMBL1637329 | 0.81 | HDAC8 (0.39) | HDAC8BACE1RAB9ACYP1A2CYP2D6 | |
| SCHEMBL31394603 | 0.79 | HDAC8 (0.38) | HDAC8BACE1LMNARAB9ACYP1A2 | |
| SCHEMBL27553581 | 0.78 | HDAC6 (0.33) | HDAC6 | |
| SCHEMBL10173626 | 0.76 | ALDH1A1 (0.39) | HDAC8HTR2ALMNARAB9AHTR2B | |
| SCHEMBL16569404 | 0.75 | HDAC8 (0.40) | HDAC8BACE1LMNAHTTMAPT | |
| SCHEMBL146444 | 0.75 | HDAC8 (0.38) | HDAC8BACE1RAB9ACYP1A2CYP2D6 | |
| SCHEMBL3351415 | 0.75 | IRAK4 (0.40) | HDAC8BACE1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL21411441 | 0.75 | IRAK4 (0.38) | HDAC8BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901664-B | Pyridone compounds and uses thereof | 南京再明医药有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-114901664-A | Pyridone compound and application thereof | 江苏先声药业有限公司 | 2022-08-12 | — | — | CN | disclosed |
| WO-2021139775-A1 | PYRIDONE COMPOUND AND APPLICATION | 江苏先声药业有限公司 | 2021-07-15 | — | — | WO | disclosed |
| WO-2021139775-A1 | PYRIDONE COMPOUND AND APPLICATION | 江苏先声药业有限公司 | 2021-07-15 | — | — | WO | disclosed |
| CN-100509807-C | Indazole derivative for pestide | SINGENTA CO LTD (GB) | 2009-07-08 | — | — | CN | disclosed |
| US-7112553-B1 | Pesticidal indazole or benzotriazole derivatives | SYNGENTA LIMITED (GB) | 2006-09-26 | — | — | US | disclosed |
| CN-1535966-A | Indazole derivative for pestide | — | 2004-10-13 | — | — | CN | disclosed |
| CN-1156472-C | Pesticidal benzotriazole derivatives | — | 2004-07-07 | — | — | CN | disclosed |
| EP-1171437-B1 | PESTICIDAL INDAZOLE OR BENZOTRIAZOLE DERIVATIVES | SYNGENTA LTD (GB) | 2003-10-08 | — | — | EP | disclosed |
| CN-1351603-A | Indazole or benzotriazole derivatives for use as pesticides | ZENECA LTD (GB) | 2002-05-29 | — | — | CN | disclosed |
| EP-1171437-A1 | PESTICIDAL INDAZOLE OR BENZOTRIAZOLE DERIVATIVES | Syngenta Limited (GB) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000063207-A1 | PESTICIDAL INDAZOLE OR BENZOTRIAZOLE DERIVATIVES | SYNGENTA LIMITED (GB) | 2000-10-26 | — | — | WO | disclosed |