SCHEMBL28878435

SCHEMBL28878435

C[Si](C)(C)Nc1nc2c(Cl)cccc2s1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.66
GAA P10253 6/20 0.66
LMNA P02545 6/20 0.66
MEN1 O00255 6/20 0.66
MAPT P10636 6/20 0.66
ALDH1A1 P00352 5/20 0.66
HPGD P15428 3/20 0.66
TDP1 Q9NUW8 3/20 0.66
MAPK1 P28482 2/20 0.66
PKM P14618 2/20 0.66
PDE10A Q9Y233 1/20 0.53
PSMB8 P28062 1/20 0.53
TSHR P16473 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
SENP7 Q9BQF6 2/20 0.46
CASP3 P42574 1/20 0.46
SENP8 Q96LD8 1/20 0.46
SENP6 Q9GZR1 1/20 0.46
ACP1 P24666 1/20 0.45
RAB9A P51151 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29974340 1.00 KMT2A (0.66) KMT2AGAALMNAMEN1MAPT
SCHEMBL2139042 0.79 KMT2A (1.00) KMT2AGAALMNAMEN1MAPT
SCHEMBL9038665 0.79 KMT2A (0.64) KMT2AGAALMNAMEN1MAPT
SCHEMBL14184987 0.79 GAA (0.64) KMT2AGAALMNAMEN1MAPT
SCHEMBL30754208 0.76 DYRK1A (0.71) KMT2AGAALMNAMEN1MAPT
SCHEMBL1747928 0.76 LMNA (0.66) KMT2AGAALMNAMEN1MAPT
SCHEMBL11206066 0.75 KMT2A (0.64) KMT2AGAALMNAMEN1MAPT
SCHEMBL2433144 0.74 LMNA (0.63) KMT2AGAALMNAMEN1MAPT
SCHEMBL31527876 0.74 KMT2A (0.62) KMT2AGAALMNAMEN1MAPT
SCHEMBL2615997 0.73 LMNA (0.61) KMT2AGAALMNAMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115151536-A Antiviral compounds, compositions and methods of use 不列颠哥伦比亚大学 2022-10-04 CN disclosed