Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 16/20 | 0.59 |
| ▸ | F11 | P03951 | 3/20 | 0.55 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28337878 | 0.91 | KLKB1 (0.57) | KLKB1F11CACNA1HBTK | |
| SCHEMBL28339182 | 0.89 | KLKB1 (0.59) | KLKB1F11CACNA1H | |
| SCHEMBL20549483 | 0.87 | KLKB1 (0.70) | KLKB1F11BTK | |
| SCHEMBL17785343 | 0.83 | KLKB1 (0.74) | KLKB1F11 | |
| SCHEMBL28339177 | 0.81 | F11 (0.70) | KLKB1F11 | |
| SCHEMBL31339412 | 0.81 | KLKB1 (0.63) | KLKB1F11BTK | |
| SCHEMBL16246724 | 0.81 | KLKB1 (0.63) | KLKB1F11BTK | |
| SCHEMBL17785375 | 0.78 | KLKB1 (0.58) | KLKB1F11BTK | |
| SCHEMBL17785367 | 0.74 | KLKB1 (1.00) | KLKB1F11 | |
| SCHEMBL17785389 | 0.74 | KLKB1 (0.80) | KLKB1F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108576-B | N- ((hetero) arylmethyl) -heteroaryl-carboxamide compounds as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2020-03-10 | — | — | CN | disclosed |
| CN-110577519-A | N- ((hetero) arylmethyl) -heteroaryl-carboxamide compounds as plasma kallikrein inhibitors | 卡尔维斯塔制药有限公司 | 2019-12-17 | — | — | CN | disclosed |