SCHEMBL28880759

SCHEMBL28880759

Cc1ccc(S(=O)(=O)/C=C/c2ccc(Br)cc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR9 Q9NR96 1/20 0.60
ALDH1A1 P00352 3/20 0.49
MAPT P10636 2/20 0.49
TDP1 Q9NUW8 2/20 0.49
TP53 P04637 2/20 0.49
KMT2A Q03164 2/20 0.49
NPC1 O15118 1/20 0.49
NFKB1 P19838 1/20 0.49
S100A4 P26447 1/20 0.49
MTOR P42345 1/20 0.49
RAB9A P51151 1/20 0.49
NFKB2 Q00653 1/20 0.49
RELA Q04206 1/20 0.49
MEN1 O00255 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
HPGD P15428 1/20 0.49
MAPK1 P28482 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28343916 0.91 TLR9 (0.72) TLR9ALDH1A1MAPTTDP1TP53
SCHEMBL16828395 0.83 NFE2L2 (0.60) TLR9ALDH1A1MAPTTDP1TP53
SCHEMBL15497047 0.83 TLR9 (0.60) TLR9ALDH1A1MAPTTDP1TP53
SCHEMBL1195505 0.83 TLR9 (0.60) TLR9ALDH1A1MAPTTDP1TP53
SCHEMBL1195446 0.83 NFE2L2 (0.53) NFE2L2HDAC1HDAC8MAOB
SCHEMBL15511636 0.83 TLR9 (0.60) TLR9ALDH1A1MAPTTDP1TP53
SCHEMBL1195448 0.83 NFE2L2 (0.53) NFE2L2HDAC1HDAC8MAOB
SCHEMBL1195502 0.83 TLR9 (0.60) TLR9ALDH1A1MAPTTDP1TP53
SCHEMBL16828394 0.83 NFE2L2 (0.60) TLR9ALDH1A1MAPTTDP1TP53
SCHEMBL1194075 0.82 TLR9 (0.53) TLR9ALDH1A1KMT2AMEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108623503-B Green preparation method of vinyl sulfone derivative in water phase 宁波大学 2020-01-03 CN disclosed