Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | ABL2 | P42684 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.45 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | CTSE | P14091 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15156055 | 0.94 | SRC (0.55) | SRCEGFRABL1ABL2GPR119 | |
| SCHEMBL15145742 | 0.94 | SRC (0.55) | SRCEGFRABL1ABL2GPR119 | |
| SCHEMBL14798023 | 0.90 | SRC (0.48) | SRCEGFRABL1ABL2GPR119 | |
| SCHEMBL31626196 | 0.90 | SRC (0.48) | SRCEGFRABL1ABL2GPR119 | |
| SCHEMBL16321782 | 0.88 | SRC (0.49) | SRCEGFRABL1ABL2GPR119 | |
| SCHEMBL16321781 | 0.88 | SRC (0.49) | SRCEGFRABL1ABL2GPR119 | |
| SCHEMBL12596571 | 0.87 | GPR119 (0.45) | SRCEGFRGPR119HCAR1RET | |
| SCHEMBL20480736 | 0.87 | SRC (0.42) | SRCEGFRABL1ABL2GPR119 | |
| SCHEMBL30760919 | 0.85 | SRC (0.47) | SRCEGFRABL1ABL2GPR119 | |
| SCHEMBL30760832 | 0.85 | SRC (0.47) | SRCEGFRABL1ABL2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304606-B | Degradation agent for simultaneously targeting BTK and GSPT proteins | 清华大学 | 2024-04-19 | — | — | CN | disclosed |
| CN-115304606-A | Degradation agent for simultaneously targeting BTK and GSPT1 proteins | 清华大学 | 2022-11-08 | — | — | CN | disclosed |