Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.30 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.30 |
| ▸ | GABRP | O00591 | 2/20 | 0.30 |
| ▸ | GABRD | O14764 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27648191 | 1.00 | POLB (0.35) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27770660 | 1.00 | POLB (0.35) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27926922 | 0.85 | PSEN1 (0.34) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27945526 | 0.85 | PSEN1 (0.34) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13101598 | 0.83 | SMN1; SMN2 (0.43) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15798464 | 0.82 | MAPK1 (0.41) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27780989 | 0.82 | MAPK1 (0.41) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27719737 | 0.82 | MAPK1 (0.41) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28670967 | 0.81 | PSEN1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27893644 | 0.81 | LMNA (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114981259-B | Novel heterocyclic compound | 豪夫迈·罗氏有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-115916784-A | Novel imidazopyrazine derivatives | 豪夫迈·罗氏有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-114981259-A | Novel heterocyclic compound | 豪夫迈·罗氏有限公司 | 2022-08-30 | — | — | CN | disclosed |