Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.33 |
| ▸ | NPY4R | P50391 | 4/20 | 0.32 |
| ▸ | NPY1R | P25929 | 3/20 | 0.32 |
| ▸ | NPY2R | P49146 | 2/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL16279880 | 1.00 | PRCP (0.33) | PRCPNPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL6027855 | 1.00 | PRCP (0.33) | PRCPNPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL28033048 | 1.00 | PRCP (0.33) | PRCPNPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL28736891 | 0.97 | KDM1A (0.32) | PRCPNPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL29157307 | 0.96 | PRCP (0.35) | PRCPNPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL4278540 | 0.96 | PRCP (0.35) | PRCPNPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL28552748 | 0.95 | PRCP (0.35) | PRCPNPY4RNPY1RNPY2RNPY5R | |
| Arginine SCHEMBL28469088 | 0.95 | PRCP (0.35) | PRCP | |
| Arginine SCHEMBL29206209 | 0.95 | PRCP (0.35) | PRCP | |
| Arginine SCHEMBL29255555 | 0.95 | PRCP (0.35) | PRCPNPY4RNPY1RNPY2RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107157928-B | Matrix metalloproteinase responsive polymer drug carrier and preparation method and application thereof | 中国科学技术大学 | 2020-02-07 | — | — | CN | disclosed |